Biological explorations with nanoscale secondary ion mass spectrometry
نویسندگان
چکیده
منابع مشابه
Advances in imaging secondary ion mass spectrometry for biological samples.
Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructu...
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This article is a concise review of the application of secondary ion mass spectrometry (SIMS) to the imaging of biological cells. The paper covers the various advantages and disadvantages of different approaches to SIMS analysis with respect to the information that can be gained from the interrogation of the cells. Current successes, pitfalls and future potential for SIMS in cell imaging are di...
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mental standards, and by statistical and systematic errors in the measurement of x-ray lines and in the separation of line intensity from spectral background. The errors in estimating the characteristics of the detector system, with exception of deadtime effects, cancel when the emission from the specimen is divided by that from the standard. The estimate of achievable accuracy of EPMA and the ...
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Liquid secondary-ion mass spectrometry (liquid SIMS) is an obsolescent ionization technique that revolutionized the analyses of large biological molecules in the 1980s. The term includes fast atom bombardment mass spectrometry (FAB-MS). The technique has been largely superseded by electrospray ionization. This account will cover the history of the technique, the principles of the operation, and...
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Imaging with cluster secondary ion mass spectrometry (SIMS) is reaching a mature level of development. Using a variety of molecular ion projectiles to stimulate desorption, 3-dimensional imaging with the selectivity of mass spectrometry can now be achieved with submicrometer spatial resolution and <10 nm depth resolution. In this Perspective, stock is taken regarding what it will require to rou...
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ژورنال
عنوان ژورنال: Journal of Analytical Atomic Spectrometry
سال: 2019
ISSN: 0267-9477,1364-5544
DOI: 10.1039/c9ja00171a